Biography
Biography: Amr Amin
Abstract
The multikinase inhibitor, sorafenib, remains for a decade now the first and only systemic therapy for the treatment of hepatocellular carcinoma (HCC). Thus, a novel approach against HCC is essential for a better therapeutic outcome. The aim of this study is to assess the chemopreventive action of Saffron’s main biomolecules against chemically-induced liver cancer in rats, and to explore the mechanisms by which Saffron’s biomolecules employ their anti-tumor effects. We provide a network analysis of differentially expressed genes in tissues of animals pre-treated with Saffron’s biomolecules in comparison to induced-HCC animals’ tissue. To further support our results, we assessed the in vitro effects of those natural products on cells viability and cell cycle distribution. Network analysis was also conducted and identified NF-kB as a potential regulatory hub, and therefore, a candidate therapeutic drug target.