Drug Induced Liver Injury (DILI)

Drugs are an important cause of liver damage. More than nine hundred medications, toxins, and herbs have been reported to cause liver damage, and drugs represent twenty to forty percent of all cases of fulminant hepatic failure. Roughly seventy five percent of the idiosyncratic drug reactions result in liver transplantation or death. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug. Knowledge of the commonly implicated agents and a high index of suspicion are essential in diagnosis.

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