Liver specific proteome
Human liver physiology and the genetic etiology of the liver diseases can potentially be elucidated through the identification of proteins with enriched expression in the liver. The combined data from RNA sequencing and antibody-based immunohistochemistry across all major human tissues explore the human liver proteome with enriched expression, as well as the cell type-enriched expression in hepatocyte and bile duct cells. Identification of the biological processes and metabolic functions associated with these proteins investigated their contribution in the occurrence of liver diseases, and identified potential targets for their treatment.
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